This is something I have been chasing for a while. Multiple characters from separate LoRAs interacting with each other. There are many regional conditioning solutions available, but as soon as you try to add LoRA data to the conditioning channels, the LoRA data seems to overrun the whole generation.

A8R8 just released a clean regional prompting solution - https://github.com/ramyma/A8R8_ComfyUI_nodes

If you blend that with ADE_RegisterLoraHook and ADE_ConditioningSetMaskAndCombine nodes, it is possible to have the LoRA constrained to its section of the generation.